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Tuesday 10th of November 2020
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Unprecedented market situation going on @mcm_ct
World Of Finance
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Salvation through vaccination would be dangled like a cat toy in front of fearful populations, @MichaelPSenger The Spinning Top
Misc.
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That said do you (or anyone else) know what 90% efficacy means? Is that the observed difference in infection rates between vaccinated / placebo, or does this refer to reduction in symptom severity / duration @BallouxFrancois
Misc.
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@pfizer .@TheRealMakori
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Here we go round the prickly pear Prickly pear prickly pear Here we go round the prickly pear At five o’clock in the morning.
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Ranthambhore right now. @adityadickysin
Asia
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''You felt the land taking you back to what was there a hundred years ago, to what had been there always.”
Africa
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"A parking lot between a sex shop and a crematorium" This may be the most painfully accurate description of adult life. @BallouxFrancois
Law & Politics
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The Way We Live Now
World Of Finance
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Multi-sensory Vincent van Gogh exhibition @lonelyplanet
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Bwindi Impenetrable National Park is the fairy-tale forest we dreamed about as children; it is also primaeval – one of Africa’s oldest ecosystems. @africageo
Africa
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This is a landscape wrapped in a blanket of mist; verdant, muddy, and bursting with the secret sounds of hidden life. Precipitous slopes descend to deep valleys cut into the landscape by tumbling, mountainous streams and the air is filled with the clamorous calls of forest birds unseen in the canopy.
From ancient hardwood trees interspersed with bamboo thickets to delicate fern fronds, dangling vines and vicious nettles, the word “Bwindi” literally translates to “impenetrable” in the local Runyakitara language of Uganda.
Bwindi is a UNESCO world heritage site that is home to almost half the world’s mountain gorillas; an island of biodiversity surrounded by rural Ugandan farmlands.
While there are many aspects to your Bwindi safari, the vast number of tourists that visit every year come to spend time with mountain gorillas – one of Africa’s most famous animals.
For many, this is a once-in-a-lifetime, spiritual experience with these sentient great apes.
Once on the verge of extinction, mountain gorilla numbers have been steadily increasing in the last decade, with the most recent estimate putting the number of wild mountain gorillas at over 1,000 individuals.
Over 450 of these individuals are found in Bwindi Impenetrable Forest, making it one of the population’s strongholds.
Uganda is one of the most exceptional birding destinations in Africa and home to half of all of Africa’s bird species, with a count of about 1,065 species.
The Bwindi Impenetrable Forest ecosystem alone offers a chance to spot 350 species, including 23 of the 24 Albertine Rift endemics.
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Political Reflections
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“The crisis consists precisely in the fact that the old is dying and the new cannot be born; in this interregnum, a great variety of morbid symptoms appear. now is the time of monsters.”
Law & Politics
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22-JUN-2020 :: Whoever Controls The Narrative Controls The World
Law & Politics
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And it all left me wondering Who exactly is controlling the Console?
I thought to myself This all has the Imprimatur of the "political technologist of all of Rus." And non linear War Specialist Vladislav Surkov.
The underlying aim, Surkov says, is not to win the war, but to use the conflict to create a constant state of destabilised perception, in order to manage and control
Conclusions
We have entered a Surkov moment in the US
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U.S. Attorney-General William Barr told federal prosecutors on Monday to look into “substantial” allegations of irregularities in last week’s election @globeandmail
Law & Politics
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Barr told prosecutors that “fanciful or far-fetched claims” should not be a basis for investigation and that his letter did not indicate the Justice Department had uncovered voting irregularities affecting the outcome of the election.
But he did say he was authorizing prosecutors to “pursue substantial allegations” of irregularities of voting and the counting of ballots.
Richard Pilger, who for years has served as director of the Election Crimes Branch, announced in an internal email that he was resigning from that post after he read “the new policy and its ramifications.”
Biden’s campaign said Barr was fueling Trump’s far-fetched allegations of fraud.
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09-NOV-2020 :: The Spinning Top
World Of Finance
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The World has spun at dizzying speed in 2020 and is bookended with the Decapitation of Qasem Soleimani and then the Political decapitation of President Trump by the [not so] ''Sleepy'' Joe Biden and who exits stage left twittering into the wilderness or is it Trump TV?
The demise of the Reality TV Star turned seriously vaudeville with Mr. Giulani mounting the last stand from the Four Seasons Total Landscaping next to Fantasy Island Adult Books across the street from the Delaware Valley Cremation Center.
Some Folks seem convinced that the Prophet of Populism Donald J. Trump is going to lead his 70m Disciples into some major 5th generational chess moves but surely just as likely is an Unfolding psychological breakdown played out in front of our eyes on TV like Willy Loman in Arthur Miller's Death of Salesman
“You can't eat the orange and throw the peel away - a man is not a piece of fruit.”
“If personal meaning, in this cheer leader society, lies in success, then failure must threaten identity itself.”
I’m tired to the death. The flute has faded away. He sits on the bed beside her, a little numb. I couldn’t make it. I just couldn’t make it, Linda.
Counterintuitively, The Trump Vladislav Surkov Talking Points which of course always feature George Soros are strangely ineffective and a little like a receding tide.
Biden has stayed on Point and his pithiness has been the clearest Signal in the Noise. The American Electoral System has emerged unscathed and in fact looks robust.
“My take on Trump is that he is an inevitable creation of this unreal normal world,” Adam Curtis says.
“Politics has become a pantomime or vaudeville in that it creates waves of anger rather than argument. Maybe people like Trump are successful simply because they fuel that anger, in the echo chambers of the internet.”
The Single biggest Issue remains how Biden engages with the Algorithmic Master [Blaster] and Sun Tzu Maestro ''
''The supreme art of war is to subdue the enemy without fighting''
Xi salami-sliced his way into a deeply forward position during the Obama Administration and in 2020 snaffled up Hong Kong, marched 400 kilometers into Indian Territory and the Straw Man Narendra Modi has not even uttered a word and Xi might even decide to roll over Taiwan during this Interregnum
Xi did not even turn up for Trump's beloved Trade Deal and then proceeded to shred it and surely the apex of his achievement in 2020 was releasing a bio-engineered #COVID19 and spreading it around the World with the help of all the ''shameless pro-Party hacks who chirrup hosannahs at every turn''
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‘’Zoonotic’’ origin was one that was accelerated in the Laboratory.
Misc.
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There is also a non negligible possibility that #COVID19 was deliberately released
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It is impossible to ignore the introduction of a PRRA insert between S1 and S2: it sticks out like a splinter. This insert creates the furin cleavage site
Misc.
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The CCP appears to have modeled its lockdown fraud on Event 201, so Gates, Hopkins, and the WEF would play into their hands [@MichaelPSenger]
Forcing professionals into their homes forced them into the CCP’s controlled information environment. Isolating intelligent people in the digital realm allowed the CCP to control public opinion through its army of bots and stakes in most media sources. @MichaelPSenger
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They now turn to rule over the people by means of what could be dubbed “big data totalitarianism” and “WeChat terror.” @ChinaFile #COVID19 Xu Zhangrun
Law & Politics
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Also 和谐 hexie over the eyes means "harmony" (from former Pres Hu catchphrase). In China if you've been censored you've been "harmonised".
Law & Politics
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That‘s right, we, We the People, for [as I have previously said] how can we let ourselves ―survive no better than swine; fawn upon the power-holders like curs; and live in vile filth like maggots?
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You will all be no better than fields of garlic chives, giving yourselves up to being harvested by the blade of power, time and time again. @ChinaFile #COVID19
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It’s no coincidence that “Zoom meetings” suddenly became the staple of professional work. Zoom is the CCP’s personal panopticon—the CCP can and does tune into Zoom calls anytime they want. What better way to monitor dissenting opinions.
Law & Politics
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The CCP’s financial ties with social media companies and nonprofits tasked with policing “misinformation” would facilitate the censorship necessary to prevent leaders from easing the public’s COVID hysteria. @MichaelPSenger
Law & Politics
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The Infodemic as per the preeminent Exponent @DrTedros
Law & Politics
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“We call on all countries to implement decisions that are evidence-based and consistent,” said Tedros. Roger that. [Epsilon Theory]
There‟s just one problem.
The “evidence” here – taken without adjustment or question from the CCP – was a baldfaced lie. And everyone at WHO knew it.
Fake news is now defined as anything that disputes WHO data, which means that fake news is now defined as anything that disputes the official China party line.
Where possible, China wants to criminalize any speech ... any social media ... that does not follow the official party line. Where it‟s not possible to criminalize that speech, China wants to ban it through the cooperative censorship of global tech and media platforms.
#Coronavirus how the @WHO is leading the social media fight against misinformation @DrTedros @SCMPNews http://j.mp/32gPzxX
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Salvation through vaccination would be dangled like a cat toy in front of fearful populations, each vaccine proving futile—but a great excuse to bill national governments for mandatory vaccine programs, another milestone in the end of human rights.
Law & Politics
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THE VACCINE STORY IS ANOTHER MYTH
Misc.
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No-one has ever produced a safe and effective vaccine against a coronavirus. Birger Sørensen, Angus Dalgleish & Andres Susrud
What if, as I fear, there will never be a vaccine. I was involved in the early stages of identifying the HIV virus as the cause of Aids. I remember drugs companies back then saying there would be a vaccine within around 18 months. Some 37 years on, we are still waiting. Prof ANGUS DALGLEISH @MailOnline
Therefore, we have to ask ourselves does the Biden ''Inflexion'' Point seek to seriously engage the Chinese Advance or is Game Over?
Of course, Biden will seek to engage on a more coherent and multilateral Basis but will that be enough?
There is no V shaped recovery coming in 2021. Thats just a Fantasy.
"As a consequence of decades of economic mismanagement, sequential resuscitations and constant bailouts—most especially during the past three years—vast portions of the global economy have mutated into a ‘zombified’ state." @mtmalinen
And the Virus is not going away anytime in fact it is now exponential.
"The greatest shortcoming of the human race is our inability to understand the exponential function." - Professor Allen Bartlett
Malcolm Gladwell „‟Tipping Point‟‟ moment in an epidemic when a virus reaches critical mass. It‟s the boiling point. It‟s the moment on the graph when the line starts to shoot straight upwards.
Just to be clear, both worldwide daily cases and worldwide daily deaths are now rising and at their maximum.
Global record 642,697 new #COVID19 cases yesterday grew total cases 1.3% yesterday to 49,314,356. Total deaths now 1,242,618 with exponential increase of 0.64% per day accelerating faster than cases. @jmlukens
Global #COVID19 cases exponentially growing on average 1.12% per day and now total 49,824,177. World on track to 100M cases by end of year at current rate. @jmlukens
I have been watching True Detective
Rustin Cohle from True Detective says,
"Time is a flat circle. Everything we have done or will do we will do over and over and over again- forever."
So where do we go from here in the Markets?
The one consistent Theme is
The Print Shop
The $DXY heads lower
The Renminbi puts on muscle through Year End.
Therefore You better find a Shelter from the incoming Storm
Gold [Looks like we get a clean move towards $2,300.00]
Silver of course is Gold on Steroids.
The FAO Food Price Index [BUY]
Sell Crude Oil on any Price Spikes [because the World is as shut down in 2021 as it has been in 2020]
The Internet Surge will continue to gain traction - My Choice is Netflix partly because of the rapid internationalisation of its content.
Turning to Africa
So far Africa has dodged the Virus from a medical perspective though it remains in my view a slow burning Fuse and we all
know by now ''viruses exhibit non-linear and exponential characteristics'
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Morocco 4,436 avg #COVID19 cases per day up 33% past two weeks. Algeria avg cases per day up 93% past 2wks. @jmlukens
Africa
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COVID-19 avg Daily Case Increase #Algeria: 93% #Botswana: 75% #Uganda: 74% #Ghana: 71% #Kenya: 62% #Nigeria: 51% #Morocco: 33% #Libya: 5% #Angola: 4%
The real challenge is the Economic Emergency.
The latest Regional Economic Outlook for Sub-Saharan Africa projects economic activity in the region to decline by 3.0% in 2020 and recover by 3.1% in 2021. @IMFNews
The IMF is so bright eyed and bushy tailed and I want some of whatever Pills they are popping.
Ethiopia which was once the Poster child of the African Renaissance now has a Nobel Prize Winner whom I am reliably informed
PM Abiy His inner war cabinet includes Evangelicals who are counseling him he is "doing Christ's work"; that his faith is being "tested". @RAbdiAnalyst
@PMEthiopia has launched an unwinnable War on Tigray Province.
Democracy from Tanzania to Zimbabwe to Cameroon has been shredded.
We are getting closer and closer to the Virilian Tipping Point
“The revolutionary contingent attains its ideal form not in the place of production, but in the street''
Political leadership in most cases completely gerontocratic will use violence to cling onto Power but any Early Warning System would be warning a Tsunami is coming
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10 NOV 14 : African youth demographic {many characterise this as a 'demographic dividend"} - which for Beautiful Blaise turned into a demographic terminator
Africa
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Martin Aglo, a law student from Benin, told Reuters: “After the Arab Spring, this is the Black Spring”.We need to ask ourselves; how many people can incumbent shoot stone cold dead in such a situation – 100, 1,000, 10,000?
This is another point: there is a threshold beyond which the incumbent can’t go. Where that threshold lies will be discovered in the throes of the event.
The Event is no longer over the Horizon.
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Saudi "Crown Prince Mohammed bin Salman remained silent on the U.S. vote for hours even as he sent warm words to the [autocratic] president of Tanzania on his re-election." @KenRoth
Law & Politics
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.@JoeBiden pledged in his campaign to reassess ties with the kingdom, demanding more accountability over the killing of Saudi journalist Jamal Khashoggi in Riyadh’s Istanbul consulate and calling for an end to U.S. support for the Yemen war. @Reuters
Law & Politics
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“The only thing worse than COVID-19 would be BIDEN-20,” wrote Saudi Twitter user Dr Muna, while many other Saudi users of the social media platform simply ignored the result in the initial hours after U.S. networks called the election for Biden.
A Saudi political source played down the risk of a falling out between the kingdom and the United States, pointing to Riyadh’s historic ties with Washington.
But Saudi Arabia’s Okaz newspaper offered a sense of the uncertainty about how the future plays out for the kingdom. “The region is waiting ... and preparing ... for what happens after Biden’s victory,” it wrote in a front page article.
The kingdom may not have to wait long. Neil Quilliam, associate fellow at Britain’s Chatham House think-tank, said the Biden administration would likely seek to signal early on its discontent with Saudi domestic and foreign policies.
“The Saudi leadership is concerned that a Biden administration and a hostile Congress will carry out a full review of relations, including re-evaluating defence ties and therefore will likely make positive sounds and moves towards ending the Yemen conflict,” he said.
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13-NOV-2017 :: an unwinnable war in Yemen
Law & Politics
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Global #COVID19 cases now total 50,386,783. World avg cases/day increased 29% past 2wks. @jmlukens
Misc.
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Average COVID-19 cases/day
#US: 108k
#France: 53k
#India: 46k
#Italy: 32k
#UK: 22k
#Spain: 20k
#Germany: 19k
#Russia: 19k
#Brazil: 16k
#Czechia: 10k
55 countries: >1k
101 countries: >100
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Malcolm Gladwell „‟Tipping Point‟‟ moment in an epidemic when a virus reaches critical mass. It‟s the boiling point. It‟s the moment on the graph when the line starts to shoot straight upwards. #nCoV2019
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It took only 8 days to the next million US confirmed covid cases. The 1st million took > 100 d @EricTopol
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April 29 1 million
June 11 2 million
July 8 3 million
July 24 4 million
Aug 9 5 million
Aug 31 6 million
Sept 26 7 million
Oct 17 8 million
Oct 31 9 million
Nov 8 10 million
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27-JUL-2020 :: Drinking the Kool-Aid The exponential moment is still in front of us. #COVID19
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Europe 313,373 #COVID19 cases yesterday exponentially grew total cases 2.52% to 12,417,934. 3704 avg deaths per day up 124% past two weeks. @jmlukens
Misc.
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19-OCT-2020 :: Now Is The Winter Of Our Discontent
World Of Finance
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Arundhati Roy: ‘The pandemic is a portal’ – The Open Question is a Portal to whence.
Misc.
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But unlike the flow of capital, this virus seeks proliferation, not profit, and has, therefore, inadvertently, to some extent, reversed the direction of the flow. Arundhati Roy: ‘The pandemic is a portal’ @FT
Misc.
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A virulent plague that “travelled through the air as if on wings, it burned through cities like fire”.
Misc.
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International Markets
World Of Finance
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Currency Markets at a Glance WSJ
World Currencies
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Euro 1.1828
Dollar Index 92.646
Japan Yen 104.98
Swiss Franc 0.9120
Pound 1.3178
Aussie 0.7284
India Rupee 74.1675
South Korea Won 1115.25
Brazil Real 5.3856
Egypt Pound 15.672
South Africa Rand 15.4050
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Dollar Index Chart INO 92.652
World Currencies
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Euro versus the Dollar Chart 1.1826
World Currencies
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Commodity Markets at a Glance WSJ
Commodities
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Crude Oil Chart INO 39.83
Minerals, Oil & Energy
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I think the CBRT’s failed defence of the lira via FX intervention including thru state owned banks will go down in the annals of central bank history as an epic failure - costs? Perhaps $120-140bn for the period 19-20 according to one US bank. @tasheco
Emerging Markets
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. In 1998, Prime Minister Margaret Thatcher told the House of Commons: “There is no way in which one can buck the market.”
Law & Politics
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August 13, 2018 And then ‘’Even if they got dollars, we got ‘our people, our God’’’ [In the markets that is called a ‘’Hail Mary’’ pass]
Emerging Markets
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He said, “Don’t get high on your ambitions. You won’t be able make money on the back of this nation. You won’t be able to make this nation kneel.”
“The edge...There is no honest way to explain it because the only people who really know where it is are the ones who have gone over,” [Hunter. S. Thompson]
President Erdogan is right at the edge.
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04.09.2018 no-one except die-hard Erdogan-supporting Turkish nationalists is prepared to throw good money after money gone bad on the basis of Erdogan's hocus pocus monetary policy Mr. Satchu told Sputnik.
Emerging Markets
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Ethiopia federal army backed by #Amhara regional forces capture #Dansha town in #Tigray region after deadly fighting against #TPLF troops that killed hundreds of soldiers according to Reuters. @MoradNews
Africa
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Conclusions
Turning and turning in the widening gyre The falcon cannot hear the falconer
https://rich.co.ke/srch/results.php?str=turning
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Zambia 'doing everything possible' to avoid looming default - finance minister @Reuters @JoeBavier
Africa
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Zambia is doing everything possible to avoid a sovereign debt default later this week, including sharing information on its Chinese debt with holders of its dollar-denominated bonds, its finance minister told Reuters on Monday.
Sources close to the main committee of bondholders, however, said little progress had been made in debt talks.
Even before the coronavirus pandemic caused a global economic slowdown, Zambia was struggling with mounting debt due to low prices for copper, its main export.
It has three outstanding dollar-denominated Eurobonds with a total face value of $3 billion.
It missed payment of a $42.5 million coupon on one of its Eurobonds last month and has asked creditors to delay interest payments until April, a request that has so far failed to receive support from bondholders.
A 30-day “grace period” on the coupon payment expires on Friday.
“We’ll wait and see. We’re doing everything possible,” Finance Minister Bwalya Ng’andu told Reuters by ‘phone. “The discussions (with bondholders) are on a continuous basis.”
When asked whether Zambia had the resources to pay the coupon within the grace period, he said his country had committed to treating all its creditors the same.
Its dollar bonds are currently trading between 44-46 cents on the dollar, according to Tradeweb data.
With the pandemic adding to pressure on some African countries already struggling with unsustainable debt, Zambia is being closely watched as a test case for how borrowers and creditors might navigate a broader debt crisis.
Eurobond holders have cited Zambia’s lack of progress in talks with the International Monetary Fund (IMF) and poor transparency regarding its borrowing from China as obstacles to their agreeing to its request to suspend debt payments.
Ng’andu said his government had shared requested information with creditors.
“We’ve given all the information that needs to be given concerning the Chinese debt,” he said.
However, the source close to the Zambia External Bondholder Committee - a large group of creditors holding more than 40% across all of Zambia’s bonds and a blocking stake in each issue - said they still did not have enough clarity.
“Creditors have not received detailed information on the Chinese debt,” the source said, adding that no discussions of substance had been going on.
A second source said creditors had “very low visibility on the terms, conditions and alleged arrears on Chinese or other commercial debt as well as specific proposed treatment of it.”
Zambia’s debt-to-GDP ratio is expected to top 100% this year, having ballooned from just over 30% in 2014.
Its external public debt burden is around $12 billion. Some $3.5 billion of that is bilateral debt, $2.1 billion is owed to multilaterals and $2.9 billion is other commercial debt in addition to the $3 billion of Eurobonds.
It owes about $3 billion to China and Chinese entities.
The China Development Bank agreed late last month to defer repayment on a loan to Zambia, but Eurobond holders say the deal’s announcement lacked details such as the loan’s size and terms.
Ng’andu said Zambia would continue to engage with Chinese institutions to seek further debt relief.
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December 9, 2019 They are still popping Quaaludes in Lusaka.
Africa
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The Kwacha is 21 to a US dollar. @HHichilema
Africa
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14-OCT-2019 :: Ozymandias The Canary in the Coal Mine is Zambia.
Africa
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High prevalence of pre-existing serological cross-reactivity against SARS-CoV-2 in sub-Sahara Africa #COVID19 International Journal of Infectious Diseases
Africa
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•High prevalence of serological cross-reactivity against SARS-CoV-2 in pre-COVID-19 pandemic plasma samples from sub-Sahara Africa.
•Pre-COVID-19 pandemic plasma displayed strong reactivity against other human coronaviruses.
•Exposure to other coronaviruses may induce cross-reactive antibodies against SARS-CoV-2 in sub-Sahara Africa.
Significant morbidity and mortality from SARS-CoV-2 has been experienced in America, Europe and Asia; whereas, the number of infections and deaths in sub-Sahara Africa (SSA) has remained comparatively low.
One hypothesis is that population in SSA has been exposed to other coronaviruses prior to the COVID-19 pandemic and resulted in some degree of cross-protection against SARS-CoV-2 infection and pathogenesis.
Our goal was to evaluate this hypothesis by comparing SARS-CoV-2 cross-reactive antibodies in pre-pandemic plasma samples collected from SSA and USA.
Pre-COVID-19 pandemic plasma samples from SSA and USA were collected and tested by immunofluorescence assay against the spike and nucleocapid proteins of all known human coronaviruses (HCoV).
Results
Significantly higher prevalence of SARS-CoV-2 serological cross-reactivity was detected in samples from SSA compared to USA.
Majority of these cross-reactive samples cross-recognized SARS-CoV-2 nucleocapsid protein together with recognition of spike proteins from other HCoVs.
Since nucleocapsid proteins from HCoV-NL63 and HCoV-229E were detected by majority of samples, it implicates prior exposure to these two HCoVs as the likely source for cross-reactive antibodies against SARS-CoV-2.
Conclusion
Low SARS-CoV-2 infection and disease in SSA appears to correlate with pre-pandemic serological cross-recognition of HCoVs, which are substantially more prevalent in SSA than USA.
SARS-CoV-2 is a betacoronavirus and a close relative to the original SARS and Middle East respiratory syndrome coronavirus (MERS) which both cause lethal diseases in human (Chen et al., 2020, Gussow et al., 2020).
There are four other less pathogenic human coronaviruses (HCoV), HCoV-OC43, HCoV-HKU-1, HCoV-NL63 and HCoV-229E that cause mild upper respiratory tract disease referred to as the “common cold” (Chen et al., 2020, Gussow et al., 2020).
A potential factor could be the relatively younger African populations as compared to that in America or Europe. This may result in more asymptomatic cases (Gaye et al., 2020).
Additionally, if the onerous high infectious disease burden in SSA includes exposure to human coronaviruses, this could elicit humoral responses against conserved epitopes among coronaviruses that might engender cross-protection.
This prior exposure to other coronaviruses may offer some level of cross-protective immune responses against SARS-CoV-2 infection, thereby, reducing either the number and/or severity of COVID-19 cases.
To investigate this hypothesis, we examined pre-COVID-19 pandemic Tanzanian, Zambian and USA plasma samples for serological cross-reactivity against the spike and nucleocapsid proteins of SARS-CoV-2 and other human coronaviruses (SARS, MERS, HCoV-OC43, HCoV-HKU-1, HCoV-NL63 and HCoV-229E), as well as whether HIV-1 infection, which is endemic in SSA, could affect the prevalence of serological cross-reactive against SARS-CoV-2.
We found that pre-COVID-19 pandemic sub-Saharan African samples have a significantly higher prevalence of serological cross-reactivity against SARS-CoV-2 than samples from the USA.
Additionally, SARS-CoV-2 cross-reactive plasma samples strongly recognized the spike and nucleocapsid proteins from specific human seasonal coronaviruses, suggesting prior exposure to these other coronaviruses may induce partially protective responses against SAR-CoV-2.
Among our cohort, 6.7% and 43.4% of the Tanzania and Zambia samples, respectively, were HIV-1 positive. Whereas all plasma samples collected in the USA were HIV-1 negative.
The high prevalence of HIV-1 infection in the Zambian samples does not reflect the national HIV-1 infection rates, but rather was intended to support comparison of cross-reactivity against SARS-CoV-2 and recognition of other coronaviruses between HIV-1 positive and negative subjects.
Despite the rapid spread of SARS-CoV-2 and causing nearly a million deaths worldwide to date, the SARS-CoV-2 burden in sub-Sahara Africa remains surprisingly low.
This is despite a high prevalence of other diseases such as HIV-1, malaria, cancer and tuberculosis, and in addition to insufficient health care and the impact of poverty.
Coincidently, the current SARS-CoV-2 disease burden is much higher in the USA than sub-Saharan African countries.
Whether this low prevalence of serological cross-reactivity to HCoV in the USA, as we report here, is directly associated with the outcomes of the USA COVID-19 pandemic remains unknown.
Our data suggests that populations in sub-Sahara Africa had been pre-exposed to a spectrum of HCoVs that have provided some cross-reactivity against SARS-CoV-2 and may have limited infections or pathogenesis on the continent.
In support of this hypothesis, our study detected serological cross-reactivity against SARS-CoV-2 antigens in pre-COVID-19 plasma samples from Tanzania and Zambia at levels nearly 8- and 6-fold, respectively, higher than the prevalence in samples from the USA.
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Fig. 1 Immunofluorescence assay (IFA) against either mock, SARS-CoV-2 spike or nucleocapsid expressing cells.
Africa
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Representative pictures of IFA with negative control plasma, COVID-19 convalescence plasma (positive control) and pre-COVID-19 pandemic cross-reactive plasma samples 21928 and 21933.
Sample 21928 displayed cross-reactivity against SARS-CoV-2 spike, but not its respective mock and SARS-CoV-2 nucleocapsid.
Sample 21933 displayed cross-reactivity against SARS-CoV-2 nucleocapsid, but not its respective mock and SARS-CoV-2 spike. White arrows indicate positive cells. Scale bar represent 50 µm.
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Fig. 2 Percent prevalence of serological cross-reactivity against SARS-CoV-2 among Tanzania, Zambia and USA.
Africa
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(A) Combined serological cross-reactivity against SARS-CoV-2 spike and nucleocapsid. (B) Serological cross-reactivity against SARS-CoV-2 nucleocapsid. (C) Serological cross-reactivity against SARS-CoV-2 spike.
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Fig. 3 Immunofluorescence assay (IFA) against SARS, MERS, HCoV-OC43, HCoV-HKU-1, HCoV-NL63 and HCoV-229E spike or nucleocapsid expressing cells.
Africa
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Representative pictures of IFA with pre-COVID-19 pandemic cross-reactive plasma samples 21854.
Sample 21854 strongly recognized the spike protein of HCoV-OC43, HCoV-HKU-1, HCoV-NL63 and HCoV-229E, but not SARS and MERS.
Sample 21854 only recognized the nucleocapsid of HCoV-NL63 and not the other human coronaviruses. White arrows indicate positive cells. Scale bar represent 50 µm.
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Fig. 4 Percent prevalence of serological cross-reactivity against SARS, MERS, HCoV-OC43, HCoV-HKU-1, HCoV-NL63 and HCoV-229E. (A) Spike. (B) Nucleocapsid.
Africa
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The Origin of the #CoronaVirus #COVID19
Africa
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South Africa All Share Bloomberg
Africa
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Dollar versus Rand Chart INO 15.4062
World Currencies
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Egypt Pound versus The Dollar Chart
World Currencies
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Egypt EGX30 Bloomberg 15.6682
Africa
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Ghana Stock Exchange Composite Index Bloomberg
Africa
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17.51% 756 people have tested positive for the virus, from a sample size of 4,316 tested in the last 24 hours @MOH_Kenya
Africa
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Exponential, non linear and multiplicative.
Africa
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Kenya Human Rights Commission @thekhrc accuses agriculture co. Kakuzi of manipulating witnesses to withdraw from UK lawsuit over violent abuse by security guards. @BHRRC
Law & Politics
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Kenyans launched a legal claim with @LeighDay_Law against Camellia Plc last month
N.S.E Equities - Agricultural
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Kakuzi share price data
N.S.E Equities - Agricultural
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Kenya Shilling versus The Dollar Live ForexPros 108.90
World Currencies
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Nairobi All Share Bloomberg
N.S.E General
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Nairobi ^NSE20 Bloomberg
N.S.E General
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Every Listed Share can be interrogated here
N.S.E General
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